Atypical Neuroleptics in Plasma / Serum - On-Line Analysis
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The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called “atypical” neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intra- and interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) especially for olanzapine and clozapine is „strongly recommended“*. Here, the complete kit of RECIPE represents a fully automated, robust on-line technique, that allows to inject the samples directly (i.e. without manual sample preparation) into the HPLC system. *Recommendations for TDM according to the consensus guidelines of the AGNP-TDM Expert Group, Germany, 2005: Olanzapine, clozapine: „strongly recommended“; risperidon plus 9-OH-risperidone: „recommended“, quetiapine: „useful“. |
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Test Data |
HPLC Parameters |
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Sample Preparation
Chromatograms |
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| Chromatogram of the plasma calibrator, order no. 40013 (+ 20 µl Internal Standard IS per ml sample, order no. 40012) |
Chromatogram of the plasma calibrator, order no. 40113 (+ 10 µl Internal Standard IS per ml sample, order no. 40012) | |
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| Desmethylolanzapine (D-Olz): 9.51 min, Olanzapine (Olz): 11.15 min, Desmethylclozapine (D-Clz): 12.27 min, Internal Standard: 14.43 min, Clozapine (Clz): 18.55 min, Quetiapine (Qtp): 20.25 min | Paliperidone (Plp): 10.47 min, Risperidone (Rsp): 11.68 min, Internal Standard IS: 16.65 min |
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Ordering Information
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